منابع مشابه
Alternative Splicing and Tumor Progression
Alternative splicing is a key molecular mechanism for increasing the functional diversity of the eukaryotic proteomes. A large body of experimental data implicates aberrant splicing in various human diseases, including cancer. Both mutations in cis-acting splicing elements and alterations in the expression and/or activity of splicing regulatory factors drastically affect the splicing profile of...
متن کاملRole of Aberrant Alternative Splicing in Cancer
Alternative splicing can alter genome sequence and as a consequence, many genes change to oncogenes. This event can also affect protein function and diversity. The growing number of study elucidate the pathological influence of impaired alternative splicing events on numerous disease including cancer. Here, we would like to highlight the significant role of alternative splicing in cancer biolog...
متن کاملAlternative Splicing: Role in Cancer Development and Progression
1 Dipartimento di Biomedicina e Prevenzione, Università di Roma Tor Vergata, Via Montpellier 1, 00133 Roma, Italy 2 Fondazione Santa Lucia, Laboratorio di Neuroembriologia, Via del Fosso di Fiorano 64, 00143 Roma, Italy 3 Faculty of Health and Life Sciences, University of the West of England, Coldharbour Lane, Bristol BS16 1QY, UK 4 Istituto di Genetica Molecolare, Consiglio Nazionale delle Ric...
متن کاملUXT-AS1-induced alternative splicing of UXT is associated with tumor progression in colorectal cancer.
Increasing evidence indicates that long non-coding RNAs (lncRNAs) can act as crucial regulators of tumor progression. In the present study, UXT-AS1 was found to be significantly upregulated in colorectal cancer (CRC) and high expression levels of UXT-AS1 were significantly associated with poor prognosis in CRC patients. In addition, upregulation of UXT-AS1 resulted in inhibition of cell apoptos...
متن کاملEvolution and Alternative Splicing
In order to comprehend the influence of evolutionary changes in gene structure on the alternative splicing mechanism, we work on three related subjects: (i) conservation of exonintron sequences, (ii) splice site score changes and (iii) length data changes, across the vertebrate tree. We have analyzed conservation levels of human Alternative cassette exons (ACEs) ...
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ژورنال
عنوان ژورنال: Current Genomics
سال: 2008
ISSN: 1389-2029
DOI: 10.2174/138920208786847971